Synthetic approaches to enantiomerically pure 8-azabicyclo[3.2.1]octane derivatives
Article Abstract:
The 8-azabicyclo[3.2.1]octane framework (tropane), occurring both in natural and in synthetic compounds is of considerable interest because of the wide range of biological activities that these substances display. Methodologies that provide enantioselective routes to chiral substituted 8-azabicyclo[3.2.1]octane nuclei, and synthetic approaches to several specific targets are developed.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
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Stereoselective anhydride openings
Article Abstract:
The newly developed methods to carry out diastereo- and enantioselective desymmetrization of cyclic meso-anhydrides are reviewed. The methods could be applied to generate optically active intermediates to synthesize biologically active natural products.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2007
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